revolve1
revolve2
revolve3
revolve4
spacer
spacer



Allergy show


Tesco


FFE


ads home page 1


Foodcycle


Fria


ads home page 8


Short stature of celiac disease children linked with pituitary abnormality

Anti-Pituitary Antibodies in Children With Newly Diagnosed Celiac Disease: A Novel Finding Contributing to Linear-Growth Impairment

Am J Gastroenterol 2010; 105:691–696; doi:10.1038/ajg.2009.642; published online 10 November 2009

OBJECTIVES:
The possible autoimmune involvement of the pituitary gland in patients with celiac disease (CD) has been suggested but demonstrated in only a few patients on gluten-free diet. We aimed to assess the prevalence and clinical meaning of anti-pituitary antibodies (APA) in children and adolescents with the newly diagnosed CD.

METHODS:
A total of 119 patients with CD (0.9–15.8 years old) attending the inpatient clinic of University Hospital were recruited for the cross-sectional study. Their height, weight, and body mass index (BMI) were recorded, and insulin-like growth factor-1 (IGF-1) and APA were assayed. APA was also determined in 98 sex- and age-matched controls.

RESULTS:
APA were detected in 50 patients (42.0%), 15 of them with high titer (30%) and 35 with low titer (70%), and in 2 control subjects at low titer (2%) (P<0.001). IGF-1 was higher in patients with negative than with low titer (P=0.02) or high titer APA (P=0.03). Height was more reduced in high-titer APA patients than in the negative ones (P<0.01). Height was positively correlated with IGF-1 (P<0.01) and negatively with chronological age (P=0.001). IGF-1 was positively correlated with BMI (P<0.001). For height prediction the regression analysis showed the rank order 1 for chronological age and 2 for IGF-1.

CONCLUSIONS:
In this paper we have shown a remarkable prevalence of positive APA in newly diagnosed CD patients. High APA titers are associated with height impairment, likely mediated by a reduction of IGF-1, thus suggesting that autoimmune pituitary process could induce a linear-growth impairment.

Click here for more research on coeliac disease

 

 

Top of page

stumbleupon twitter About facebook digg
twitter spacer facebook

Click here for NEW FreeFrom Events CALENDAR


Click here to subscribe to our FREE E-NEWSLETTER
Click here to see a recent issue


Click here for our BLOG


Click here for recent
ARTICLES & RESEARCH
on CoeliacsMatter


Click here gluten-free
COOKERY COURSES



The cost of gluten-free bread.
Lucinda Bruce-Gardyne, founder of Genius Gluten Free, explains why gluten-free bread genuinely does cost a lot more to make than 'normal' supermarket bread.



Coeliac Disease and Gluten Sensitivity: A Clinical Perspective.

Study day run by The Academy for Paediatric Gastroenterology and Coeliac UK.
Alex Gazzola reports.


All about Marmite...
Sue Cane investigates whether the
love-it-or-hate-it spread really
is suitable for coeliacs – or not ...


Gluten Summit – the overview
Micki Rose pulls together the findings
of the 2014 Gluten Summit.