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Research reports on coeliac disease and its causes

Research references are listed, as nearly as possible, by the dates on which the research was first published or brought into the public domain.

Dysbiosis of microbiota is associated with persistent gastrointestinal symptoms in treated celiac disease patients and open new possibilities to treat this subgroup of patients. November 2014

Researchers identify why some people with celiac disease show an immune response after eating oats. Novmeber 2014

Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange. November 2014

Celiac disease triggers may include non-gluten proteins. November 2014

Coeliac disease does not increase the risk of death from cancer. Report here. 2014

Early gluten exposure no protection against celiac disease. October 2014

Delaying the introduction of gluten-containing foods to babies at risk for celiac disease doesn't prevent the condition from developing in those children, nor does breastfeeding prevent it. September 2014

Diversity of the cultivable human gut microbiome involved in gluten metabolism: isolation of microorganisms with potential interest for coeliac disease. March 2014

More than 25% of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5. July 2014

Gluten sensitivity is commonly self-reported with symptoms suggesting an association with irritable bowel syndrome. The majority of patients have NCGS, not coelaic disease. January 2014

Aphthous-like ulcers are a risk indicator for coeliac disease, and a gluten-free diet ameliorates ulcers. February 2008

Differentiating between celiac disease (CD) and non-celiac gluten sensitivity (NCGS): a diagnostic algorithm. May 2014

Fourfold increase in rate of diagnosed cases of coeliac disease in the UK. May 2014

Study aims to isolate and characterise the human gut bacteria involved in the metabolism of gluten proteins. May 2014

Increased prevalence of celiac disease in children with irritable bowel syndrome. April 2014

Elafin, a human protein, plays a key role against the inflammatory reaction typical of coeliac disease. Researchers have developed probiotic bacterium to deliver Elafin to the gut of mice. Comment in Science Daily. April 2014

Coeliacs may have a near two-fold increased risk of coronary artery disease compared with the general population. March 2014

Chronic intestinal damage raises hip-fracture rate in celiac disease patients. January 2014

Celiac disease Is diagnosed less frequently in young adult males. January 2014

Autoimmune diseases such as coeliac disease, rheumatoid arthritis, MS, Crohn’s, lupus and colitis appear to arise out of small DNA changes located outside the genes themselves. December 2013

Coeliac disease more common in children with higher socio-economic status  although this may be party due to more frequent diagnosis amongst this group.  November 2013

Decreased risk of celiac disease in patients with Helicobacter pylori. October 2013

Nationwide Swedish  study finds no association between CD or inflammation and earlier Autistic Spectrum Disorders, there was a markedly increased risk of ASDs in individuals with normal mucosa but a positive CD serologic test result. September 2013

People with celiac disease whose intestines are slow to heal could be at increased risk of cancer of the immune system, or lymphoma. August 2013

Antibiotic exposure has positive association with the development of coeliac disease. 2013

Combining gene tests with blood tests could increase the accuracy and reduce the need for invasive diagnostic tests for coeliac disease. Research here; comment here. August 2013

Coeliac disease, originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now equally common in all these countries. It is still thought to be rare in the Orient and Sub-Saharan Africa although wheat consumption there is now of the same order as in Western Europe so CD may become more common in the future. August 2013

Neuro, gut and thyroid disorders common in coeliacs despite GF diet. Comment here. July 2013

Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity.  May 2013

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.  May 2013

Patients who had previously been prescribed antisecretory medications, including proton pump inhibitors and histamine-2 receptor antagonists at increased risk for developing celiac disease. May 2013

75% of coeliacs have lower bone mineral density. May 2013

Prevalence and natural history of potential celiac disease in adult patients. March 2013

Glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins – result – most of the diseases and conditions associated with a Western diet such as coeliac disease, autism, cancer and Alzheimer’s disease. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases.  January 13

Oral and dental issues such as enamel defects and mouth ulcers may be an indication of coeliac disease. December 2012

New research indicates that repeated infections early in life increase the risk of developing coeliac disease. It is not known whether the problem is the infections themselves or the antibiotics frequently prescribed to treat them, antibiotics being known to seriously disrupt the gut microbiome. December 2012

Gluten-free diet reduces weight gain, inflammation and insulin resistance in mice. December 2012

Introducing small amounts of gluten along with breastfeeding from four months onwards appears to reduce the incidence of coeliac disease at the age of 12. November 2012

Migraine more prevalent in those with coeliac disease and inflammatory bowel disorders so it would be prudent to screen  migraineurs for CD. November 2012

Although coeliac disease is associated with a small increase in the risk of bone fracture and malignancy (the latter in the first year after diagnosis), it is also associated with a marked reduction in the risk of breast and lung cancer. October 2012

Undiagnosed coeliac disease can often be a cause of dysmotility, indigestion and IBS. October 2012 

Genetic testing an important tool to identify first degree relatives who may be susceptible to coeliac disease. October 2012

Screening blood from 4,000 healthy blood donors in Brazil showed that one in every 286 subjects had indiagnosed coelaic disease, of whom 67% were of European origin. September 2012

ESPGHAN diagnostic criteria work well in selected population. November 2012

Brain abnormality in patients with coeliac disease. August 2012

Frequency of coeliac disease in Asians. August 2012

Persistent bone pain may be a sign of coeliac disease. March 2012

Maternal antibodies to gluten linked to schizophrenia risk in children. May 2012

Goblet cells in the intestine may play a much more important role than had been thought in the transport of potential allergens to dendritic cells which, in turn, spark immune system allergic and autoimmune reactions in inflammatory bowel disease, coeliac disease and allergies. April 2012

Could maize/corn be as damaging for coeliacs as wheat? February 2012

High prevalence of coeliac disease among first degree relatives of coeliac patients. January 2012

Capsule endoscopy increasingly used to diagnose coeliac disease because it is non-invasive and provides a close and magnified view of the mucosa of the entire small bowel. An update of current data. January 2012

Gluten contamination in the Canadian commercial oat supply. June 2011

Information on gluten-containing cosmetics is not so easy to find. October 2011

Influence of breast milk versus formula and genetics on gut microbiota composition could help prevent coeliac disease. August 2011

Genetic study sheds light on auto-immune arthritis which may have relevance for coeliac disease. July 2011

Could coeliac disease be implicated in some deaths from childhood diarrhoea?
July 2011

Spring/summer born children more likely to have coeliac disease. May 2011

In adults with coeliac disease, intestinal damage doesn’t always heal. March 2011

Mouse study suggests new chemical clues to coeliac disease. February 2011

The prevalence of coeliac disease in Europe: results of a centralised, international mass screening project. December 201

Increased risk of thyroid cancer in coeliac patients. August 2010

Saliva test for coeliac disease successful. November 2010

Coeliac patients in Sweden at greater risk of influenza hospital admission.
September 2010

Elderly people more likely to develop coeliac disease than children. 
September 2010

Family stress does not appear to be a cause of childhood coeliac disease.
September 2010

IBS patients have signficantly higher risk of being coeliac than those who do not suffer from the condition. December 2009

Toxic fragments in gluten which cause coeliac disease finally identified. 
July 2010

Viral infections may be implicated in coeliac disease. July 2010

Can coeliac disease cause infertility? May 2010

Does a Caesarean delivery increase a child’s risk of becoming coeliac?
May 2010

Blood tests provide accurate diagnostic alternative to biopsy in coeliac disease.
June 2010

Short stature of coeliac disease children linked with pituitary abnormality.
March 2010

Cystic fibrosis is a risk factor for coeliac disease. March 2010

Gluten intolerance doubles in Finland. No suitable criteria for diagnosis exist, says Finnnish expert. March 2010

Coeliac disease could originate in a viral infection. March 2010

Five simple questions to find hidden coeliac disease in children. February 2010

Recurrent infections in small children could be caused by silent coeliac disease.
February 2010

Rate of coeliac diagnosis has increased since introduction of antibody test.
December 2009

More research suggests that coeliac disease can shorten lifespan.
September 2009

Immune system found to attack bone tissue in coeliacs.
October 2009

Coeliac disease four times more common than in 1950s and, if undiagnosed, four times more likely to kill you... October 2009

Mouth ulcers a possible indication of coeliac disease. October 2009

Increasing prevalence and high incidence of coeliac disease in elderly people.
June 2009

Untreated coeliac disease may affect the brain and shorten lifespan. April 2009

Coeliac disease and B vitamins. April 2009

Coeliac disease and anaemia. March 2009

Coeliac disease and Type 1 diabetes share some gene variants.
October 2008

Nine coeliac gene regions identified, four of which predispose to type 1 diabetes.
September 2008

The botany of gluten. June 2007

Coeliac disease increases TB risk. June 2007

Some infections may increase childhood coeliac risk. April 2007

Integrative Manual Therapy (IMT) for gluten sensitivity. February 2007

Possible relationship between myopathies and coeliac disease. February 2007

Potential coeliac disease/dementia link discovered. January 2007

Is there a link between coeliac disease and Inflammatory Bowel Disease?
July 2006


Articles on coeliac disease


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