Allergy show



ads home page 1



ads home page 8

Cystic fibrosis is a risk factor for celiac disease. 03/10

Walkowiak J, Blask-Osipa A, Lisowska A, Oralewska B, Pogorzelski A, Cichy W, Sapiejka E, Kowalska M, Korzon M, Szaflarska-Pop?awska A.
Department of Dietetics, Pozna? University of Life Sciences, Pozna?, Poland.

Acta Biochim Pol. 2010;57(1):115-8. Epub 2010 Mar 20.

The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence of CD in CF patients to that in the general population at the same time. There is no published data on genetic predisposition to CD in CF patients either. Therefore, in the present study we aimed to assess the genetic predisposition to CD and its incidence in CF patients comparing it to data from the general population.

Two hundred eighty-two CF patients were enrolled in the study. In 230 CF patients the genetic predisposition to CD (the presence of HLA-DQ2/ DQ8) was assessed. In all CF patients, serological screening for CD was conducted. In patients with positive antiendomysial antibodies (EMA) gastroduenoscopy was offered. Intestinal histology was classified according to modified Marsh criteria. The results of serological CD screening in 3235 Polish schoolchildren and HLA-DQ typing in 200 healthy subjects (HS) were used for comparison.

Positive EMA was found in 2.84% of the studied CF patients. The incidence of proven CD was 2.13%. The incidence of CD as well as positive serological screening were significantly more frequent in the CF group than in the general population. The frequency of CD-related HLA-DQ alleles in CF and HS did not differ.

Genetic predisposition to celiac disease in cystic fibrosis patients is similar to that of the general population. However, our results suggest that cystic fibrosis is a risk factor for celiac disease development.


Click here for more research on coeliac disease



Top of page

stumbleupon twitter About facebook digg
twitter spacer facebook

Click here for NEW FreeFrom Events CALENDAR

Click here to subscribe to our FREE E-NEWSLETTER
Click here to see a recent issue

Click here for our BLOG

Click here for recent
on CoeliacsMatter

Click here gluten-free

The cost of gluten-free bread.
Lucinda Bruce-Gardyne, founder of Genius Gluten Free, explains why gluten-free bread genuinely does cost a lot more to make than 'normal' supermarket bread.

Coeliac Disease and Gluten Sensitivity: A Clinical Perspective.

Study day run by The Academy for Paediatric Gastroenterology and Coeliac UK.
Alex Gazzola reports.

All about Marmite...
Sue Cane investigates whether the
love-it-or-hate-it spread really
is suitable for coeliacs – or not ...

Gluten Summit – the overview
Micki Rose pulls together the findings
of the 2014 Gluten Summit.